Format

Send to

Choose Destination
See comment in PubMed Commons below
World J Gastroenterol. 2006 Sep 7;12(33):5363-7.

In vitro and in vivo effects of ferulic acid on gastrointestinal motility: inhibition of cisplatin-induced delay in gastric emptying in rats.

Author information

  • 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt. obadary@yahoo.com

Abstract

AIM:

To study the effects of ferulic acid on gastrointestinal motility both in vitro and in vivo.

METHODS:

Ferulic acid induced concentration-dependent stimulation of the basal tone of isolated guinea pig ileum (2-20 micromol/L) and isolated rat fundus (0.05-0.4 mmol/L).

RESULTS:

Ferulic acid significantly accelerated the gastrointestinal transit and gastric emptying in rats in a dose-dependent manner (50-200 mg/kg, po). Cisplatin (2.5-20 mg/kg, ip) induced a dose-dependent delay in gastric emptying in rats. Pretreatment with ferulic acid dose-dependently, significantly reversed the cisplatin-induced delay in gastric emptying.

CONCLUSION:

The endogenous prostaglandins (PGs) are involved in mediating the stimulant effects of ferulic acid. This effect of dietary ferulic acid may help improve other accompanying gastrointestinal symptoms such as abdominal discomfort and also may protect against emesis induced by cytotoxic drugs.

PMID:
16981269
PMCID:
PMC4088206
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk