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Cutan Ocul Toxicol. 2006;25(3):211-6.

Percutaneous absorption of crotamiton in man following single and multiple dosing.

Author information

  • 1Universit√† degli Studi di Bologna, Dipartimento di Medicina Clinica Specialistica e Sperimentale Sezione di Clinica Dermatologica, Italy. emi.dika@tin.it

Abstract

PURPOSE:

Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin.

METHODS:

We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose regimen by measuring urinary excretion and liquid scintillation counting in three groups of four healthy volunteers. The Feldmann urinary excretion method was utilized to ascertain percutaneous absorption. Our results showed that tape stripping does not increase percutaneous absorption of crotamiton; upon repeated application.

PMID:
16980246
[PubMed - indexed for MEDLINE]
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