Tolling for autoimmunity-prime time for 7

Immunity. 2006 Sep;25(3):397-9. doi: 10.1016/j.immuni.2006.08.011.

Abstract

The reason certain self-antigens are consistently targeted by autoantibodies may be because they are self-adjuvants. Two papers in this issue of Immunity provide important insights into the contribution of Toll-like receptors in systemic autoimmune disease (Berland et al., 2006; Christensen et al., 2006).

Publication types

  • Comment

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / metabolism*
  • Humans
  • Toll-Like Receptor 7 / deficiency
  • Toll-Like Receptor 7 / genetics
  • Toll-Like Receptor 7 / physiology*
  • Toll-Like Receptor 9 / deficiency
  • Toll-Like Receptor 9 / genetics
  • Toll-Like Receptor 9 / physiology

Substances

  • TLR9 protein, human
  • Toll-Like Receptor 7
  • Toll-Like Receptor 9