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    Nature. 1990 Aug 30;346(6287):818-22.

    In vitro selection of RNA molecules that bind specific ligands.

    Ellington AD, Szostak JW.

    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.

    Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 10(10) random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.

    PMID: 1697402 [PubMed - indexed for MEDLINE]

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