Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):973-85. Epub 2006 Aug 5.

Amyotrophic lateral sclerosis as a complex genetic disease.

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MRC Centre for Neurodegeneration Research P 043, King's College London, Institute of Psychiatry, London SE5 8AF, UK.

Abstract

In complex diseases like ALS, there are multiple genetic and environmental factors all contributing to disease liability. The genetic factors causing susceptibility to developing ALS can be considered a spectrum from single genes with large effect sizes causing classical Mendelian ALS, to genes of smaller effect, producing apparently sporadic disease. We examine the statistical genetic principles that underpin this model and review what is known about ALS as a disease with complex genetics.

PMID:: 16973338; [PubMed - indexed for MEDLINE]

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Amyotrophic lateral sclerosis as a complex genetic disease.
Amyotrophic lateral sclerosis as a complex genetic disease.
Biochim Biophys Acta. 2006 Nov-Dec ;1762(11-12):973-85. Epub 2006 Aug 5 .

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