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Psychiatr Genet. 2006 Oct;16(5):221-3.

No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia.

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  • 1Department of Psychiatry, The University of Iowa, Psychiatry Research/MEB, Iowa City, IA 52242-1000, USA.


Some serological and genetic studies have suggested that alterations in folate metabolism are associated with increased vulnerability to schizophrenia. In particular, these findings are most striking for the role of a putatively functional variant (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene. To test the hypothesis that the T allele and the TT genotype are risk factors for psychosis, we genotyped the C677T polymorphism in 206 participants with schizophrenia or schizoaffective disorder and 359 participants from a population control sample. Neither the T allele nor the TT genotype was associated with increased risk for schizophrenia. These results do not support a role for the C677T MTHFR variant in schizophrenia.

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