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Psychiatr Genet. 2006 Oct;16(5):221-3.

No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia.

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  • 1Department of Psychiatry, The University of Iowa, Psychiatry Research/MEB, Iowa City, IA 52242-1000, USA. robert-philibert@uiowa.edu


Some serological and genetic studies have suggested that alterations in folate metabolism are associated with increased vulnerability to schizophrenia. In particular, these findings are most striking for the role of a putatively functional variant (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene. To test the hypothesis that the T allele and the TT genotype are risk factors for psychosis, we genotyped the C677T polymorphism in 206 participants with schizophrenia or schizoaffective disorder and 359 participants from a population control sample. Neither the T allele nor the TT genotype was associated with increased risk for schizophrenia. These results do not support a role for the C677T MTHFR variant in schizophrenia.

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