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Dig Dis Sci. 2006 Oct;51(10):1783-90.

Multilayered epithelium may be found in patients with Barrett's epithelium and dysplasia or adenocarcinoma.

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  • 1Department of Pathology, University of Washington Medical Center, University of Washington Medical School, Seattle, Washington, USA.

Abstract

To determine if multilayered epithelium (MLE) is a useful prognostic indicator for a benign natural history of Barrett's epithelium, we evaluated endoscopic biopsies from patients with Barrett's epithelium without and with dysplasia and/or adenocarcinoma and from non-Barrett's controls for the presence of MLE. MLE was found in 6% of non-Barrett's controls, 30% of Barrett's patients with no dysplasia, and 14% of Barrett's patients with dysplasia and/or adenocarcinoma. MLE was significantly associated with shorter lengths of Barrett's epithelium in both Barrett's groups. Three of 5 photodynamic therapy patients were noted to develop MLE after therapy. MLE may be found in patients with dysplasia and/or adenocarcinoma and after photodynamic therapy; its presence is not useful as a prognostic indicator for a more benign course of Barrett's. This study confirms that MLE is significantly associated with shorter lengths of Barrett's epithelium.

PMID:
16967312
[PubMed - indexed for MEDLINE]
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