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Arch Gynecol Obstet. 2007 Apr;275(4):307-9. Epub 2006 Sep 12.

Bilateral encapsulated adipocytic prosoplasia of ovary with fat necrosis: a case report.

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  • 1Department of Pathology, Maulana Azad Medical College, New Delhi, India.


Mature adipose tissue is not a normal component of ovarian cortical stroma. Rarely, it is seen as a phenomenon termed adipocytic prosoplasia of ovarian stroma, which occurs as an unencapsulated collection of mature adipocytes. The lesions in differential diagnosis of adipocytic prosoplasia can range from reactive/benign to aggressive conditions. The exact diagnosis of this entity is essential, since no further intervention is required. We describe a case of a 45-year-old female presenting with uterine leiomyomata. Bilateral ovaries were normal on gross inspection. Microscopy of both ovaries showed circumscribed encapsulated subcapsular foci of adipose tissue with focal necrosis and calcification, suggestive of fat necrosis. No teratomatous elements were found on multiple sections examined, and a diagnosis of bilateral adipocytic prosoplasia with fat necrosis was considered. We report this case due to its intriguing and interesting finding, with an emphasis on the various differential diagnoses to be considered in such a case. Extensive examination, special stains and clinico-pathological correlation help in arriving at a proper diagnosis. Our case is the first report of an ovarian adipocytic prosoplasia with fat necrosis.

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