Neurology. 2006 Sep 12;67(5):897-9.

Effects of caffeine on levodopa pharmacokinetics and pharmacodynamics in Parkinson disease.

Deleu D, Jacob P, Chand P, Sarre S, Colwell A.

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Department of Neurology (Medicine), Sultan Qaboos University Hospital, Sultanate of Oman. doc_deleu@hotmail.com

Abstract

The authors studied the acute effect of caffeine on the levodopa pharmacokinetics and pharmacodynamics in 12 patients with idiopathic Parkinson disease. This double-blind, randomized, crossover study revealed that caffeine shortened the maximal plasma concentration of levodopa, decreased the latency to levodopa walking and tapping motor response, and increased the magnitude of walking response. Caffeine administered before levodopa may improve its pharmacokinetics in some parkinsonian patients.

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Pharmacodynamics of levodopa coadministered with apomorphine in parkinsonian patients with end-of-dose motor fluctuations. [Clin Neuropharmacol. 1998]
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