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    Am J Addict. 2006 Sep-Oct;15(5):327-35.

    Serotonin transporter genotype and acute subjective response to amphetamine.

    Lott DC, Kim SJ, Cook EH, de Wit H.

    Source

    Linden Oaks Hospital at Edward, Naperville, Illinois, USA. dlott@jhu.edu

    Abstract

    The authors have previously shown an effect of dopamine transporter genotype on acute subjective responses to d-amphetamine, which may affect risk of addiction. They now report the results of an evaluation of the role of the serotonin transporter gene (HTT) using a double-blind, placebo-controlled, crossover design in which subjects (N = 101) completed self-report measures of subjective effect. The separate and combined analyses of the gene-linked polymorphic region (5-HTTLPR) and the Intron 2 VNTR suggest that these two HTT polymorphisms may contribute to acute subjective responses to d-amphetamine with a small effect.

    PMID:
    16966188
    [PubMed - indexed for MEDLINE]

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