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Zhong Xi Yi Jie He Xue Bao. 2006 Sep;4(5):514-7.

[Effects of Cordyceps sinensis on dimethylnitrosamine-induced liver fibrosis in rats].

[Article in Chinese]

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  • 1Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Abstract

OBJECTIVE:

To study the effects of Cordyceps sinensis on dimethylnitrosamine-induced liver fibrosis in rats.

METHODS:

SD rats were divided into normal control group, untreated group and Cordyceps sinensis-treated group. The rats in each group were fed with corresponding drug for 4 weeks. The rat's liver collagen deposition was observed with collagen staining. Hydroxyproline (Hyp) contents in liver tissue of the rats in 3 groups were determined with HCl hydrolysis. The tissue inhibitor of metalloproteinase-2 (TIMP-2) and type IV collagen contents were observed by Envision, and matrix metalloproteinases-2 (MMP-2) activity was detected by the method of enzyme-picture. Type I collagen was detected by Western blotting.

RESULTS:

The contents of Hyp, TIMP-2, type IV collagen, and the expression of type I collagen in untreated group were significantly higher than those in the normal control group, while those in Cordyceps sinensis-treated group were significantly lower than those in the untreated group. The content of MMP-2 in untreated group was significantly lower than that in the normal control group, while that in Cordyceps sinensis-treated group was significantly higher than that in the untreated group.

CONCLUSION:

Cordyceps sinensis can considerably relieve the liver fibrosis, and the mechanism may be related to promoting the degradation of the collagens.

PMID:
16965748
[PubMed - indexed for MEDLINE]
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