Abstract
Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Collagen / chemistry*
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Collagen / metabolism*
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Dermatologic Agents / administration & dosage*
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Humans
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In Vitro Techniques
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Light
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Rats
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Refractometry / methods*
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Scattering, Radiation
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Skin / chemistry*
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Skin / drug effects
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Skin Absorption / drug effects
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Skin Absorption / physiology*
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Solubility
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Statistics as Topic
Substances
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Dermatologic Agents
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Collagen