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J Minim Invasive Gynecol. 2006 Sep-Oct;13(5):386-90.

Volume change of uterine myomas during pregnancy: do myomas really grow?

Author information

  • 1Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah 84132, USA. ahmad.hammoud@hsc.utah.edu

Abstract

STUDY OBJECTIVE:

To estimate changes in uterine myoma volume during pregnancy.

DESIGN:

Review of departmental electronic perinatal database and medical records. Canadian Task Force Classification II-3.

SETTING:

Obstetrical ultrasound unit in an academic tertiary care center.

PATIENTS:

One hundred-seven patients diagnosed with uterine myomas during pregnancy and who had two or more obstetrical ultrasounds in different periods of pregnancy.

INTERVENTIONS:

We analyzed the change in volume of uterine myomas between the first half of pregnancy (up until 19 weeks), third quarter (20-30 weeks), and last quarter (31 weeks to term). The volume of largest uterine myoma was calculated using the formula Volume (mm3)=Pi/6x(length mm)x(width mm)x(height mm).

MEASUREMENTS AND MAIN RESULTS:

The mean age of the population was 31+/-6 years. Between the first and the second study periods, the percentage of uterine myomas that decreased in size was 55.1% (95% CI: 43-66), with a mean decrease in volume of 35%+/-4%; while the percentage of uterine myomas that enlarged was 44.9% (95% CI: 34-56), with a mean increase in volume of 69%+/-11%. Between the second and the third study periods, 75% (95% CI: 56-87) became smaller, with a mean decrease in volume of 30%+/-3%; while 25% (95% CI: 13-43) enlarged, with a mean increase in volume of 102%+/-62%.

CONCLUSION:

Contrary to common belief, we found that uterine myomas commonly decrease in volume over the course of pregnancy.

PMID:
16962519
[PubMed - indexed for MEDLINE]
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