Biosci Biotechnol Biochem. 2006 Sep;70(9):2019-27. Epub 2006 Sep 7.

Regulation and functional relevance of milk fat globules and their components in the mammary gland.

Source

Department of Life Science, Graduate School of Bioresources, Mie University, Tsu, Japan.

Abstract

Mammary gland and epithelial cells are unique to mammals and are under the control of lactogenic hormones such as prolactin. Recent findings indicated that major components of milk fat globule membrane (MFGM) are under the control of lactogenic hormones, and that the major components butyrophilin and xanthine oxidoreductase are indispensable for milk fat secretion. Further, prolactin signaling is negatively controlled by two highly related protein tyrosine phosphatases, PTP1B and TC-PTP. Milk fat globule EGF factor 8 (MFG-E8) is one of the major components of MFGM and is upregulated during lactation. MFG-E8 is further upregulated in the involuting mammary gland. MFG-E8 on exosome-like membrane vesicles in the milk recovered from post-weaning but not lactating mammary glands exhibits higher binding activity to phosphatidylserine and apoptotic mammary epithelial cells, and serves as a link between apoptotic mammary epithelial cells and phagocytes. Recent reports using MFG-E8 deficient mice support the view that MFG-E8 is indispensable for eliminating apoptotic mammary epithelial cells during involution.

PMID:: 16960354; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

J-STAGE, Japan Science and Technology Information Aggregator, Electronic

Medical

Dietary Proteins - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity. [Biochem J. 2006]
Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity.
Nakatani H, Aoki N, Nakagawa Y, Jin-No S, Aoyama K, Oshima K, Ohira S, Sato C, Nadano D, Matsuda T. Biochem J. 2006 Apr 1; 395(1):21-30.
Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein. [Biochim Biophys Acta. 1997]
Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein.
Aoki N, Ishii T, Ohira S, Yamaguchi Y, Negi M, Adachi T, Nakamura R, Matsuda T. Biochim Biophys Acta. 1997 Mar 15; 1334(2-3):182-90.
Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8. [Proc Natl Acad Sci U S A. 2005]
Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8.
Hanayama R, Nagata S. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16886-91. Epub 2005 Nov 7.
Review The tammar wallaby and fur seal: models to examine local control of lactation. [J Dairy Sci. 2007]
Review The tammar wallaby and fur seal: models to examine local control of lactation.
Brennan AJ, Sharp JA, Lefevre C, Topcic D, Auguste A, Digby M, Nicholas KR. J Dairy Sci. 2007 Jun; 90 Suppl 1:E66-75.
Review Milk fat globule membrane components--a proteomic approach. [Adv Exp Med Biol. 2008]
Review Milk fat globule membrane components--a proteomic approach.
Cavaletto M, Giuffrida MG, Conti A. Adv Exp Med Biol. 2008; 606:129-41.

See reviews... See all...

Cited by 3 PubMed Central articles

Comparison of milk fat globule membrane (MFGM) proteins of Chianina and Holstein cattle breed milk samples through proteomics methods. [Nutrients. 2009]
Comparison of milk fat globule membrane (MFGM) proteins of Chianina and Holstein cattle breed milk samples through proteomics methods.
Murgiano L, Timperio AM, Zolla L, Bongiorni S, Valentini A, Pariset L. Nutrients. 2009 Feb; 1(2):302-15. Epub 2009 Dec 22.
In vitro culture and characterization of a mammary epithelial cell line from Chinese Holstein dairy cow. [PLoS One. 2009]
In vitro culture and characterization of a mammary epithelial cell line from Chinese Holstein dairy cow.
Hu H, Wang J, Bu D, Wei H, Zhou L, Li F, Loor JJ. PLoS One. 2009 Nov 3; 4(11):e7636. Epub 2009 Nov 3.
TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas. [Blood. 2009]
TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas.
Young RM, Polsky A, Refaeli Y. Blood. 2009 Dec 3; 114(24):5016-23. Epub 2009 Sep 15.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Regulation and functional relevance of milk fat globules and their components in...
Regulation and functional relevance of milk fat globules and their components in the mammary gland.
Biosci Biotechnol Biochem. 2006 Sep ;70(9):2019-27. Epub 2006 Sep 7 .

PubMed
Intergenerational transfers and living arrangements of older people in rural Chi...
Intergenerational transfers and living arrangements of older people in rural China: consequences for psychological well-being.
J Gerontol B Psychol Sci Soc Sci. 2006 Sep ;61(5):S256-66.

PubMed
Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to...
Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men.
Am J Clin Nutr. 2006 Sep ;84(3):623-32.

PubMed
Effects of n-3 fatty acids in subjects with type 2 diabetes: reduction of insuli...
Effects of n-3 fatty acids in subjects with type 2 diabetes: reduction of insulin sensitivity and time-dependent alteration from carbohydrate to fat oxidation.
Am J Clin Nutr. 2006 Sep ;84(3):540-50.

PubMed
Body fat distribution and risk of type 2 diabetes in the general population: are...
Body fat distribution and risk of type 2 diabetes in the general population: are there differences between men and women? The MONICA/KORA Augsburg cohort study.
Am J Clin Nutr. 2006 Sep ;84(3):483-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: