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Clin Vaccine Immunol. 2006 Sep;13(9):1064-9.

Characterization of a phenotypically unique population of CD13+ dendritic cells resident in the spleen.

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  • 1Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, 99164-7040, USA.


Immature dendritic cells (DCs) resident in bovine spleens represent a distinct CD11a(+) CD11c(+) CD13(+) CD172(+) CD205(+) population compared to those circulating in peripheral blood or trafficking via afferent lymph. Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimulation of allogeneic lymphocyte proliferation and recall antigen-specific responses.

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