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1: Science. 2006 Sep 8;313(5792):1448-50.Click here to read Links

Gene transposition as a cause of hybrid sterility in Drosophila.

Masly JP, Jones CD, Noor MA, Locke J, Orr HA.

Department of Biology, University of Rochester, Rochester, NY 14627, USA. msly@mail.rochester.edu

We describe reproductive isolation caused by a gene transposition. In certain Drosophila melanogaster-D. simulans hybrids, hybrid male sterility is caused by the lack of a single-copy gene essential for male fertility, JYAlpha. This gene is located on the fourth chromosome of D. melanogaster but on the third chromosome of D. simulans. Genomic and molecular analyses show that JYAlpha transposed to the third chromosome during the evolutionary history of the D. simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution.

PMID: 16960009 [PubMed - indexed for MEDLINE]

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