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Neuroscientist. 2006 Oct;12(5):435-41.

Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy.

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  • 1Department of Psychiatry and Behavioral Sciences University of Louisville, 500 South Preston Street, Louisville, KY, USA.


Autism is a condition manifested as abnormalities of relatedness, communication, range of interests, and repetitive behaviors. Despite alarming prevalence estimates and exhortations to research, little is known regarding its pathophysiology. Recent reports of a putative minicolumnopathy explain changes in brain size, gray/white matter ratios, and interareal connectivity. This article summarizes possible links between minicolumns and other topics-cortical modularity, age of onset, gliosis, and genetics-relevant to the pathophysiology of autism.

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