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Genes Dev. 2006 Sep 1;20(17):2355-60.

Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure.

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  • 1Department of Biochemistry and Department of Medicine, McGill University, Montreal, Canada H3A 1A1.

Abstract

A requirement for integrin-mediated adhesion in cardiac physiology is revealed through targeted deletion of integrin-associated genes in the murine heart. Here we show that targeted ablation of the integrin-linked kinase (ILK) expression results in spontaneous cardiomyopathy and heart failure by 6 wk of age. Deletion of ILK results in disaggregation of cardiomyocytes, associated with disruption of adhesion signaling through the beta1-integrin/FAK (focal adhesion kinase) complex. Importantly, the loss of ILK is accompanied by a reduction in cardiac Akt phosphorylation, which normally provides a protective response against stress. Together, these results suggest that ILK plays a central role in protecting the mammalian heart against cardiomyopathy and failure.

PMID:
16951252
[PubMed - indexed for MEDLINE]
PMCID:
PMC1560410
Free PMC Article
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