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Clin Perinatol. 2006 Sep;33(3):573-91, v.

Mechanisms of injury to the newborn brain.

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  • 1Department of Pediatrics, Division of Neonatology, St. Christopher's Hospital for Children, Front and Erie Streets, Philadelphia, PA 19134, USA.


Preterm and ill term infants are at risk for brain injury and subsequent neurodevelopmental delay as a result of many perinatal factors. Outlined in this article are the basic science mechanisms by which hypoxia, hypocapnia, and hypercapnia may result in neuronal injury in the newborn brain.

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