Preeclampsia and subsequent risk of cancer in Utah

Am J Obstet Gynecol. 2006 Sep;195(3):691-9. doi: 10.1016/j.ajog.2006.06.089.

Abstract

Objective: The purpose of this study was to determine if preeclampsia is associated with a reduced risk of cancer later in life.

Study design: We performed a cohort study where women with preeclampsia over the interval 1947 to 1999 were identified from the Utah Population Database. Preeclamptics (n = 17,432) were matched 1:3 with nonpreeclamptics (n = 52,296) on maternal age and birth year. Pregnancy, demographic, and cancer information was extracted from subjects and their offspring in linked datasets. Relative risk and hazard ratios were calculated.

Results: In a matched analysis using univariable random-effects Poisson regression, preeclampsia was protective against the development of cancer later in life (RR 0.91, 95% CI 0.84-0.99 with P = .027). In a multivariable clustered Cox regression model with the end point of cancer later in life, preeclampsia was associated with a lower risk of cancer (HR 0.92, 95% CI 0.85-0.99 with P = .039). These findings were supported by stratified and competing risk analyses.

Conclusion: Women whose pregnancies were affected by preeclampsia have a decreased risk of developing cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Confounding Factors, Epidemiologic
  • Female
  • Humans
  • Maternal Age
  • Multivariate Analysis
  • Neoplasms / epidemiology*
  • Neoplasms / mortality
  • Neoplasms / pathology
  • Pre-Eclampsia / epidemiology*
  • Pregnancy
  • Pregnancy Complications, Neoplastic / epidemiology*
  • Retrospective Studies
  • Risk
  • Utah / epidemiology