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J Proteome Res. 2006 Sep;5(9):2236-40.

Phyloproteomics: what phylogenetic analysis reveals about serum proteomics.

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  • 1Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.


Phyloproteomics is a novel analytical tool that solves the issue of comparability between proteomic analyses, utilizes a total spectrum-parsing algorithm, and produces biologically meaningful classification of specimens. Phyloproteomics employs two algorithms: a new parsing algorithm (UNIPAL) and a phylogenetic algorithm (MIX). By outgroup comparison, the parsing algorithm identifies novel or vanished MS peaks and peaks signifying up or down regulated proteins and scores them as derived or ancestral. The phylogenetic algorithm uses the latter scores to produce a biologically meaningful classification of the specimens.

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