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J Neurooncol. 2007 Mar;82(1):81-3. Epub 2006 Aug 31.

Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma.

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  • 1Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-0804, USA.


Concurrent temozolomide (TMZ) and radiotherapy is the new standard of care for patients with newly diagnosed glioblastoma. In 51 consecutive patients treated according to this regimen, 7 patients (14%) manifested surgically confirmed early necrosis without evidence of recurrent tumor. This observation suggests that daily TMZ may represent a potent radiosensitizing regimen.

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