A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis

Antimicrob Agents Chemother. 2006 Sep;50(9):3183-5. doi: 10.1128/AAC.00388-06.

Abstract

A novel natural TEM beta-lactamase with extended-spectrum activity, TEM-138, was identified in a ceftazidime-resistant clinical isolate of Salmonella enterica serovar Infantis. Compared to TEM-1, TEM-138 contains the following mutations: E104K, N175I, and G238S. The bla(TEM-138) gene was located on a 50-kb transferable plasmid. Expression studies with Escherichia coli revealed efficient ceftazidimase and cefotaximase activities for TEM-138.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Ceftazidime / pharmacology
  • Cephalosporin Resistance
  • Humans
  • Kinetics
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Salmonella enterica / drug effects
  • Salmonella enterica / enzymology*
  • Salmonella enterica / isolation & purification
  • beta-Lactamases / metabolism*

Substances

  • Ceftazidime
  • beta-Lactamases
  • beta-lactamase TEM-1

Associated data

  • GENBANK/AY853593