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Antimicrob Agents Chemother. 2006 Sep;50(9):3160-1.

Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.

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  • 1Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128-2699, USA. stevens@stanford.edu

Abstract

Concentrations above the MIC of caspofungin allow growth of some Candida isolates. A strain demonstrating paradoxical growth was grown in the presence and absence of caspofungin, and the cell wall content was analyzed. Beta-1,3-glucan declined 81% in the presence of caspofungin, as expected. Beta-1,6-glucan declined 73%. Chitin increased 898%, demonstrating a mechanism for paradoxical growth-a rapid shift in the key polymer.

PMID:
16940118
[PubMed - indexed for MEDLINE]
PMCID:
PMC1563524
Free PMC Article
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