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Antimicrob Agents Chemother. 2006 Sep;50(9):3157-9.

Interaction between fosamprenavir, with and without ritonavir, and nevirapine in human immunodeficiency virus-infected subjects.

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  • 1Orlando Immunology Center, Florida, USA.

Abstract

Fosamprenavir (FPV) with and without ritonavir (RTV) was added to the antiretroviral regimens of human immunodeficiency virus-infected subjects receiving nevirapine (NVP) to evaluate this drug interaction. Significant reductions in plasma amprenavir exposure (25 to 35%) were observed following coadministration of 1,400 mg of FPV twice a day (BID) and 200 mg of NVP BID. A regimen of 700 mg of FPV BID plus 100 mg of RTV BID may be coadministered with NVP without dose adjustment.

PMID:
16940117
[PubMed - indexed for MEDLINE]
PMCID:
PMC1563559
Free PMC Article
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