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Methods Enzymol. 2006;411:119-34.

Bioconductor: an open source framework for bioinformatics and computational biology.

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  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.


This chapter describes the Bioconductor project and details of its open source facilities for analysis of microarray and other high-throughput biological experiments. Particular attention is paid to concepts of container and workflow design, connections of biological metadata to statistical analysis products, support for statistical quality assessment, and calibration of inference uncertainty measures when tens of thousands of simultaneous statistical tests are performed.

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