Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int Rev Cytol. 2006;251:209-63.

Human hair keratin-associated proteins (KAPs).

Author information

  • 1Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany.

Abstract

Elucidation of the genes encoding structural proteins of the human hair follicle has advanced rapidly during the last decade, complementing nearly three previous decades of research on this subject in other species. Primary among these advances was both the characterization of human hair keratins, as well as the hair keratin associated proteins (KAPs). This review describes the currently known human KAP families, their genomic organization, and their characteristics of expression. Furthermore, this report delves into further aspects, such as polymorphic variations in human KAP genes, the role that KAP proteins might play in hereditary hair diseases, as well as their modulation in several different transgenic mouse models displaying hair abnormalities.

PMID:
16939781
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk