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Curr Opin Chem Biol. 2006 Oct;10(5):487-91. Epub 2006 Aug 28.

Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't.

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  • 1The Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, NY 10021, USA.


The manipulation of the chemical structure of proteins beyond what is feasible with standard genetics, offers a powerful strategy to investigate protein mechanisms. By allowing the incorporation of biophysical probes, unnatural amino acids, and post-translational modifications in proteins, chemistry-driven approaches have greatly contributed to the understanding of the molecular basis of protein function.

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