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Curr Opin Chem Biol. 2006 Oct;10(5):487-91. Epub 2006 Aug 28.

Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't.

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  • 1The Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, NY 10021, USA.

Abstract

The manipulation of the chemical structure of proteins beyond what is feasible with standard genetics, offers a powerful strategy to investigate protein mechanisms. By allowing the incorporation of biophysical probes, unnatural amino acids, and post-translational modifications in proteins, chemistry-driven approaches have greatly contributed to the understanding of the molecular basis of protein function.

PMID:
16935551
[PubMed - indexed for MEDLINE]
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