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Semin Cancer Biol. 2006 Aug;16(4):242-52. Epub 2006 Aug 4.

Mechanism of transcriptional activation by the Myc oncoproteins.

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  • 1Department of Pharmacology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA.


The Myc family proteins are potent oncogenes that can activate and repress a very large number of cellular target genes. The amino terminus of Myc contains a transactivation domain that can recruit a number of nuclear cofactors with diverse activities. Functional studies link transactivation to the ability of Myc to promote normal cell proliferation and for oncogenic transformation. The biochemical mechanism of Myc-mediated transactivation has revealed a wide range of effects on chromatin and basal transcription. This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities.

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