Am J Clin Pathol. 1990 Jun;93(6):725-30.

Lymphocytic mastopathy. An autoimmune disease of the breast?

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Department of Pathology, Mount Sinai School of Medicine, City University of New York, New York.

Abstract

Eight cases are reported of an unusual breast lesion consisting of dense intralobular, perilobular, and perivascular lymphocytic infiltrates associated with lobular atrophy and sclerosis. Immunologic studies on paraffin-embedded tissue (seven cases) and frozen tissue (two cases) demonstrated a predominance of B-cells and expression of HLA-DR antigen in involved lobular epithelium. The immunologic features of this lesion are reminiscent of lymphoepithelial lesions of salivary glands and other sites. A possible autoimmune pathogenesis is suggested.

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Am J Clin Pathol. 1990 Dec;94(6):801-2.

PMID:: 1693260; [PubMed - indexed for MEDLINE]

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Epitopes

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