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1: Semin Immunol. 2006 Oct;18(5):318-26. Epub 2006 Aug 22.Click here to read Links
Comment in:
Semin Immunol. 2006 Oct;18(5):261-2.

BLyS and B cell homeostasis.

Woodland RT, Schmidt MR, Thompson CB.

Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA. Robert.Woodland@umassmed.edu

Naïve peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.

PMID: 16931037 [PubMed - indexed for MEDLINE]

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