Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA. linkc@colorado.edu
Caenorhabditis elegans has been used to model aspects of a number of age-associated neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases. These models have typically involved the transgenic expression of disease-associated human proteins. Here I describe my laboratory's specific experience engineering C. elegans models of Alzheimer's disease, and give a general consideration of the advantages and disadvantages of these C. elegans models. The type of insights that might be gained from using these (relatively) simple models are highlighted. In particular, I consider the potential these models have for uncovering common and unique fundamental toxic mechanisms underlying human neurodegenerative diseases.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on