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Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13198-202. Epub 2006 Aug 21.

Evidence for stroke-induced neurogenesis in the human brain.

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  • 1Buck Institute for Age Research, Novato, CA 94945, USA.

Abstract

Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.

PMID:
16924107
[PubMed - indexed for MEDLINE]
PMCID:
PMC1559776
Free PMC Article
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