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Cell. 2006 Aug 25;126(4):659-62.

The inflammasome: first line of the immune response to cell stress.

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  • 1Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous "danger signals" as well as compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006, Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response.

PMID:
16923387
[PubMed - indexed for MEDLINE]
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