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    Results: 15

    1.

    The FRB domain of mTOR: NMR solution structure and inhibitor design.

    Leone M, Crowell KJ, Chen J, Jung D, Chiang GG, Sareth S, Abraham RT, Pellecchia M.

    Biochemistry. 2006 Aug 29;45(34):10294-302.

    PMID:
    16922504
    [PubMed - indexed for MEDLINE]
    2.

    Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex.

    Sarbassov DD, Sabatini DM.

    J Biol Chem. 2005 Nov 25;280(47):39505-9. Epub 2005 Sep 23.

    PMID:
    16183647
    [PubMed - indexed for MEDLINE]
    Free Article
    3.

    Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.

    Holz MK, Blenis J.

    J Biol Chem. 2005 Jul 15;280(28):26089-93. Epub 2005 May 19.

    PMID:
    15905173
    [PubMed - indexed for MEDLINE]
    Free Article
    4.

    Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.

    Chiang GG, Abraham RT.

    J Biol Chem. 2005 Jul 8;280(27):25485-90. Epub 2005 May 16.

    PMID:
    15899889
    [PubMed - indexed for MEDLINE]
    Free Article
    5.

    Characterization of the cloned full-length and a truncated human target of rapamycin: activity, specificity, and enzyme inhibition as studied by a high capacity assay.

    Toral-Barza L, Zhang WG, Lamison C, Larocque J, Gibbons J, Yu K.

    Biochem Biophys Res Commun. 2005 Jun 24;332(1):304-10.

    PMID:
    15896331
    [PubMed - indexed for MEDLINE]
    6.

    Rheb binds and regulates the mTOR kinase.

    Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.

    Curr Biol. 2005 Apr 26;15(8):702-13.

    PMID:
    15854902
    [PubMed - indexed for MEDLINE]
    7.

    Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.

    Ali SM, Sabatini DM.

    J Biol Chem. 2005 May 20;280(20):19445-8. Epub 2005 Apr 4.

    PMID:
    15809305
    [PubMed - indexed for MEDLINE]
    Free Article
    8.

    Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.

    Edinger AL, Linardic CM, Chiang GG, Thompson CB, Abraham RT.

    Cancer Res. 2003 Dec 1;63(23):8451-60.

    PMID:
    14679009
    [PubMed - indexed for MEDLINE]
    Free Article
    9.

    The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.

    Nojima H, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K, Hara K, Tanaka N, Avruch J, Yonezawa K.

    J Biol Chem. 2003 May 2;278(18):15461-4. Epub 2003 Feb 25.

    PMID:
    12604610
    [PubMed - indexed for MEDLINE]
    Free Article
    10.

    Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

    Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K.

    Cell. 2002 Jul 26;110(2):177-89.

    PMID:
    12150926
    [PubMed - indexed for MEDLINE]
    11.

    mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

    Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM.

    Cell. 2002 Jul 26;110(2):163-75.

    PMID:
    12150925
    [PubMed - indexed for MEDLINE]
    12.

    Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.

    Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Thomas G.

    J Biol Chem. 2002 May 31;277(22):20104-12. Epub 2002 Mar 25.

    PMID:
    11914378
    [PubMed - indexed for MEDLINE]
    Free Article
    13.

    Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro.

    Takahashi T, Hara K, Inoue H, Kawa Y, Tokunaga C, Hidayat S, Yoshino K, Kuroda Y, Yonezawa K.

    Genes Cells. 2000 Sep;5(9):765-75. Erratum in: Genes Cells 2000 Nov;5(11):949-52.

    PMID:
    10971657
    [PubMed - indexed for MEDLINE]
    14.

    Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro.

    Isotani S, Hara K, Tokunaga C, Inoue H, Avruch J, Yonezawa K.

    J Biol Chem. 1999 Nov 26;274(48):34493-8.

    PMID:
    10567431
    [PubMed - indexed for MEDLINE]
    Free Article
    15.

    RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

    Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM.

    Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1432-7.

    PMID:
    9465032
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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