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Brain Dev. 2007 Mar;29(2):83-91. Epub 2006 Aug 17.

Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI.

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  • 1National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China. zangyf@263.net

Erratum in

  • Brain Dev. 2012 Apr;34(4):336.

Abstract

In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01-0.08Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0+/-1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, [corrected] and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD.

PMID:
16919409
[PubMed - indexed for MEDLINE]
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