Department of Molecular Genetics, University of Texas Southwestern, Dallas, Texas 75390, USA. joachim.herz@utsouthwestern.edu
The biosynthesis and export of LDL receptor-related proteins rely on specialized chaperones in the endoplasmic reticulum. Two recent papers in Molecular Cell by Fisher et al. (2006) and Lee et al. (2006) reveal a novel mechanism by which one of these chaperones, the receptor-associated protein RAP, accomplishes this task.