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Semin Immunol. 2006 Oct;18(5):261-2.
Regulation of B cell self-tolerance by BAFF.
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia. r.brink@garvan.org.au
To avoid the generation of pathogenic autoantibodies, self-reactive lymphocytes are deleted at several distinct checkpoints during B cell maturation. BAFF is required for mature B cell development and survival but causes B cell hyperplasia and autoimmunity when it is overexpressed. Self-reactive B cells have reduced responsiveness to BAFF and therefore die due to the limiting levels of BAFF available in vivo. Elevated BAFF expression subverts B cell self-tolerance by rescuing self-reactive B cells normally deleted relatively late during maturation. Strongly self-reactive B cells are deleted prior to expression of BAFF-R and are therefore resistant to rescue by BAFF.
PMID: 16916609 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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ReviewThe BLyS family: toward a molecular understanding of B cell homeostasis.
Treml JF, Hao Y, Stadanlick JE, Cancro MP.
Cell Biochem Biophys. 2009; 53(1):1-16. Epub 2008 Nov 26.
[Cell Biochem Biophys. 2009]
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NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells.
Sasaki Y, Calado DP, Derudder E, Zhang B, Shimizu Y, Mackay F, Nishikawa S, Rajewsky K, Schmidt-Supprian M.
Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31):10883-8. Epub 2008 Jul 28.
[Proc Natl Acad Sci U S A. 2008]
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ReviewManipulating B cell homeostasis: a key component in the advancement of targeted strategies.
Treml LS, Quinn WJ 3rd, Treml JF, Scholz JL, Cancro MP.
Arch Immunol Ther Exp (Warsz). 2008 May-Jun; 56(3):153-64. Epub 2008 May 30.
[Arch Immunol Ther Exp (Warsz). 2008]
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