J Alzheimers Dis. 2006;9(3 Suppl):401-7.

Preclinical characterization of amyloid imaging probes with multiphoton microscopy.

Source

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology/Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.

Abstract

Multiphoton microscopy is an optical imaging technique that allows high resolution detection of fluorescence in thick, scattering tissues. The technique has been used for trans-cranial imaging of the brains of living transgenic mouse models of Alzheimer's disease. Direct detection of senile plaques in these mice has allowed the characterization of the natural history of individual senile plaques, the evaluation of plaque clearance during immunotherapy, and the characterization of the kinetics and biodistribution of the PET ligand, PIB. With the expanding repertoire of structural and functional fluorescent probes, and the preclinical characterization of new contrast agents for complementary imaging modalities like MRI, PET, SPECT, and NIRS, multiphoton microscopy will continue to be a powerful tool in understanding and combating Alzheimer's disease.

PMID:: 16914878; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Alzheimer's Disease - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. [Proc Natl Acad Sci U S A. 2003]
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice.
Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, Mathis CA, Klunk WE, Hyman BT. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12462-7. Epub 2003 Sep 29.
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease. [J Mol Neurosci. 2004]
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease.
Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA. J Mol Neurosci. 2004; 24(1):55-62.
Review [Molecular imaging of beta-amyloid plaques in the brain]. [Brain Nerve. 2007]
Review [Molecular imaging of beta-amyloid plaques in the brain].
Ono M. Brain Nerve. 2007 Mar; 59(3):233-40.
Review Development of positron-emission tomography/single-photon emission computed tomography imaging probes for in vivo detection of beta-amyloid plaques in Alzheimer's brains. [Chem Pharm Bull (Tokyo). 2009]
Review Development of positron-emission tomography/single-photon emission computed tomography imaging probes for in vivo detection of beta-amyloid plaques in Alzheimer's brains.
Ono M. Chem Pharm Bull (Tokyo). 2009 Oct; 57(10):1029-39.
Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease. [Brain Res. 2004]
Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease.
Kung MP, Hou C, Zhuang ZP, Skovronsky D, Kung HF. Brain Res. 2004 Oct 29; 1025(1-2):98-105.

See reviews... See all...

Cited by 2 PubMed Central articles

Review Multiphoton in vivo imaging of amyloid in animal models of Alzheimer's disease. [Neuropharmacology. 2010]
Review Multiphoton in vivo imaging of amyloid in animal models of Alzheimer's disease.
Dong J, Revilla-Sanchez R, Moss S, Haydon PG. Neuropharmacology. 2010 Sep-Oct; 59(4-5):268-75. Epub 2010 Apr 14.
Review Imaging microglial activation during neuroinflammation and Alzheimer's disease. [J Neuroimmune Pharmacol. 2009]
Review Imaging microglial activation during neuroinflammation and Alzheimer's disease.
Venneti S, Wiley CA, Kofler J. J Neuroimmune Pharmacol. 2009 Jun; 4(2):227-43. Epub 2008 Dec 4.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Preclinical characterization of amyloid imaging probes with multiphoton microsco...
Preclinical characterization of amyloid imaging probes with multiphoton microscopy.
J Alzheimers Dis. 2006 ;9(3 Suppl):401-7.

PubMed
Prognosis of proximal femoral fracture in patients aged 90 years and older.
Prognosis of proximal femoral fracture in patients aged 90 years and older.
J Orthop Surg (Hong Kong). 2006 Aug ;14(2):122-6.

PubMed
Oxidative stress-activated zinc cluster protein Stb5 has dual activator/represso...
Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production.
Mol Cell Biol. 2006 Sep ;26(17):6690-701.

PubMed
Mice with a targeted mutation of patched2 are viable but develop alopecia and ep...
Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.
Mol Cell Biol. 2006 Sep ;26(17):6609-22.

PubMed
The long-term effects of neurotoxic doses of methamphetamine on the extracellula...
The long-term effects of neurotoxic doses of methamphetamine on the extracellular concentration of dopamine measured with microdialysis in striatum.
Neurosci Lett. 1990 Mar 2 ;110(1-2):193-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Preclinical characterization of amyloid imaging probes with multiphoton microscopy.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information