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Acc Chem Res. 2006 Aug;39(8):550-7.

Domain relationships in thiamine diphosphate-dependent enzymes.

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  • 1School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.


Three-dimensional structures have been determined for 13 different enzymes that use thiamine diphosphate (ThDP) as a cofactor. These enzymes fall into five families, where members within a family have similar structures. In different families, there are similarities between some domains that clearly point to a common ancestor for all of these enzymes. Where the enzyme structures differ, evolutionary relationships between families can be discerned. Here, I present an analysis of these families and propose an evolutionary pathway to explain the diversity of structures that are now known.

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