A new medicine--Curiosin--was applied for treatment of inflammatory processes in parodontal tissues. Curiosin has no analogies by the composition and effects. It is the organotrophic medication, which includes Zinc and Hyaluronic acid. It is the glue-like, limpid solution, its pH=5-6. The Hyaluronic acid of Curiosin gets into contact with the fibrinous net and makes transitional matrix. It stipulates activity and migration of granulocytes, macrophages and fibroblasts, also - the proliferation of epithelial cells. The effectiveness and success of complex treatment was shown in 130 persons. The patients were divided into two groups: control group, n=59 persons and the study group, n=71 patients. The traditional treatment course was applied in patients of the control group. This course includes removing of gingival plaque, curette of periodontal recesses, medication of periodontal tissues with antiseptic solutions. After these preparations, periodontal tissues treated by heparin ointment and trichopol, also by periodontal bounds. In this case antibiotic-therapy was introduced. In the patients from the second-group Curiosin and plasma-therapy was applied. Before and after treatment the cytological examination was carried out in patients of both groups. For examination we got contents of periodontal recesses. Before the treatment the inflammatory processes in parodontal tissues was shown. In presence of ulcero-necrotic gingivitis, on 18-month post-operative cytogramms we saw the following results: after the treatment there was no any more processes of inflammatory-destructive character; the number of leucocytes and lymphocytes sharply decreased, while the number of undamaged cells increased. This fact can prove discontinuance of inflammation and induction of regenerative processes in periodontal tissues. We have seen the same results in groups of patients with periodontitis. Beside, there were the large number of undamaged epitheliocytes and increased number of plasmocytes.