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Pharmacol Ther. 2006 Dec;112(3):810-32. Epub 2006 Aug 14.

Synaptic plasticity and phosphorylation.

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  • 1Department of Biology, Neuroscience and Cognitive Science (NACS) Program, University of Maryland, College Park, MD 20742, USA.


A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity. Recent understanding of synaptic plasticity mechanisms underscores important roles that these synaptic phosphoproteins play in regulating both pre- and post-synaptic functions. This review will focus on key postsynaptic phosphoproteins that have been implicated to play a role in synaptic plasticity.

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