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J Occup Environ Med. 2006 Aug;48(8):771-9.

Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters.

Author information

  • 1University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104-4284, USA. emmetted@mail.med.upenn.edu

Abstract

OBJECTIVE:

The objective of this study was to determine whether certain biomarkers of toxicity and/or a past diagnosis of liver or thyroid disease were associated with serum perfluorooctanoate concentrations (PFOA) in a community with longstanding environmental exposure to PFOA.

METHODS:

Serum (PFOA), hematologic and biochemical biomarkers, and a questionnaire were administered to 371 residents selected by stratified random sampling and a lottery among volunteers. Median PFOA was 354 ng/mL (interquartile range, 181-571 ng/mL).

RESULTS:

No significant positive relationships between serum (PFOA) and liver or renal function tests, cholesterol, thyroid-stimulating hormone, or with red cell indices, white cell, or platelet counts. Mean serum (PFOA) was not increased in those with a history of liver or thyroid disease.

CONCLUSIONS:

No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed.

PMID:
16902369
[PubMed - indexed for MEDLINE]
PMCID:
PMC3038254
Free PMC Article
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