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Science. 2006 Aug 11;313(5788):839-42.

Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis.

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  • 1Department of Immunology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.

Abstract

The evolutionarily conserved actin-related protein (Arp2/3) complex is a key component of actin filament networks that is dynamically regulated by nucleation-promoting and inhibitory factors. Although much is known about actin assembly, the physiologic functions of inhibitory proteins are unclear. We generated coronin 1-/- mice and found that coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T cells. Moreover, actin dynamics, through a mitochondrial pathway, was linked to lymphocyte homeostasis.

PMID:
16902139
[PubMed - indexed for MEDLINE]
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