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J Org Chem. 2006 Aug 18;71(17):6637-9.

Iron-catalyzed homocoupling of bromide compounds.

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  • 1College of Chemical Engineering and Materials and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.


The homocoupling of bromide compounds was successfully performed in one pot by a combination of metallic magnesium and a catalytic amount of iron salts. The binary catalytic system differentiates itself from other homocoupling reactions catalyzed by iron salts in that it requires neither the in situ preparation of Grignard reagent nor the addition of a 1,2-dihalogen compound as an oxidant. Various aromatic and alkyl bromides underwent the homocoupling smoothly affording the corresponding symmetrical hydrocarbon compounds in moderate to excellent yields.

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