Epidermal growth factor and transforming growth factor-beta differently modulate the acute phase response elicited by interleukin-6 in cultured liver cells from man, rat and mouse

H Rokita; J Bereta; A Koj; A H Gordon; J Gauldie

doi:10.1016/0300-9629(90)90007-f

Epidermal growth factor and transforming growth factor-beta differently modulate the acute phase response elicited by interleukin-6 in cultured liver cells from man, rat and mouse

Comp Biochem Physiol A Comp Physiol. 1990;95(1):41-5. doi: 10.1016/0300-9629(90)90007-f.

Authors

H Rokita¹, J Bereta, A Koj, A H Gordon, J Gauldie

Affiliation

¹ Institute of Molecular Biology, Jagiellonian University, Krakow, Poland.

PMID: 1690099
DOI: 10.1016/0300-9629(90)90007-f

Abstract

1. Complex effects of principal inflammatory cytokines (IL-6, IL-1, TNF, IFN-gamma) on acute phase protein synthesis and other metabolic processes in cultured liver cells are briefly reviewed. 2. Molecular properties and biological functions of transforming growth factor-beta and epidermal growth factor are compared. 3. The effects of these factors with respect to both amino acid uptake and acute phase protein synthesis are described in detail. The results are found to be different for rat or mouse hepatocytes and human hepatoma cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acute-Phase Proteins / biosynthesis*
Acute-Phase Proteins / drug effects
Acute-Phase Reaction / physiopathology
Animals
Cells, Cultured
Epidermal Growth Factor / pharmacology
Growth Substances / pharmacology*
Humans
Interleukin-1 / pharmacology
Interleukin-6 / pharmacology
Liver / cytology*
Liver / drug effects
Liver / metabolism
Mice
Rats
Transforming Growth Factors / pharmacology
Tumor Necrosis Factor-alpha / pharmacology

Substances

Acute-Phase Proteins
Growth Substances
Interleukin-1
Interleukin-6
Tumor Necrosis Factor-alpha
Epidermal Growth Factor
Transforming Growth Factors