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Biotechnol Lett. 2006 Oct;28(20):1679-85. Epub 2006 Aug 10.

A retrovirus-based system to stably silence hepatitis B virus genes by RNA interference.

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  • 1School of Life Sciences, Sichuan University, Chengdu , 610064, China.

Abstract

RNA interference (RNAi) might be an efficient antiviral therapy for some obstinate illness. Herein, a retrovirus-based RNAi system was developed to drive expression and delivery of Hepatitis B virus (HBV)-specific short hairpin RNA (shRNA) in HepG2 cells. The levels of HBsAg and HBeAg and that of HBV mRNA were dramatically decreased by this RNAi system in HepG2 cells transfected with Topo-HBV plasmid. Retrovirus-based RNAi thus may be useful for therapy in HBV and other viral infections and provide new clues for prophylactic vaccine development.

PMID:
16900331
[PubMed - indexed for MEDLINE]
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