Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Allergy Asthma Rep. 2006 Sep;6(5):384-9.

Immune dysregulation in atopic dermatitis.

Author information

  • 1National Jewish Medical and Research Center,Department of Pediatrics, Room K926i,1400 Jackson Street, Denver, Colorado 80206, USA.

Abstract

Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors that contribute to these abnormal responses, including key effector cells of the immune system, chemokines, defective skin barrier, genetic predisposition, and environmental triggers. Understanding these pathomechanisms may improve our current therapies for atopic dermatitis.

PMID:
16899200
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk