Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Autism Dev Disord. 2007 Mar;37(3):466-80.

Studying the emergence of autism spectrum disorders in high-risk infants: methodological and practical issues.

Author information

  • 1Department of Paediatrics, McMaster Children's Hospital at McMaster University, Hamilton, Ontario, Canada. zwaigenb@mcmaster.ca

Abstract

Detecting early signs of autism is essential for timely diagnosis and initiation of effective interventions. Several research groups have initiated prospective studies of high-risk populations including infant siblings, to systematically collect data on early signs within a longitudinal design. Despite the potential advantages of prospective studies of young children at high-risk for autism, there are also significant methodological, ethical and practical challenges. This paper outlines several of these challenges, including those related to sampling (e.g., defining appropriate comparison groups), measurement and clinical implications (e.g., addressing the needs of infants suspected of having early signs). We suggest possible design and implementation strategies to address these various challenges, based on current research efforts in the field and previous studies involving high-risk populations.

PMID:
16897376
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk